Leeds have not rotated much this season, but two matches in Gameweek 25 could see head coach Marcelo Bielsa makes some changes (or not).
Manchester City will play twice in Gameweek 24, but their attack is deep enough that manager Pep Guardiola could almost fully rotate between the two matches.
Leeds have used one of the most consistent lineups in the Premier League this season, which likely means Raphinha will keep his starting spot for their matchup against Crystal Palace on Monday.
Pierre-Emerick Aubameyang returned to full training Monday, which could allow him to start Tuesday against Wolverhampton.
A number of injuries will alter lineups this weekend, with Son Heung-Min possible playing more centrally in place of the injured Harry Kane.
Liverpool went with a heavily rotated side in their last Premier League match, but Mohamed Salah seems likely to start against Spurs this week after bagging a brace against Man United in the FA Cup on Sunday.
With many teams playing twice in Gameweek 19, fantasy players will want to focus on double gameweek players.
Despite a small break in Premier League action, plenty of teams had to deal with FA Cup matches, so rotation could continue to be an issue for the six-game Gameweek 18 slate.
Dominic Calvert-Lewin has struggled a bit recently, but he'll get a boost this week as Richarlison is expected to return to the starting XI for Friday's match against West Ham.
Fantasy players should expect plenty of rotation due to the condensed holiday schedule, including the potential return of Sergio Aguero at the top of the Manchester City attack for Gameweek 16.
There could be significant rotation this weekend due to continued fixture congestion, though that likely means Mohamed Salah will return to Liverpool's starting XI.
Leeds United scored five goals in their win over Newcastle on Wednesday, which could force Marcelo Bielsa to keep his same starting XI on Sunday against Manchester United.
The busy holiday period is upon us, and we could see significant lineup rotation as Premier League sides will play midweek and again this weekend.
After playing nearly the entire match against FC Midtjylland in the Champions League on Wednesday, Diogo Jota could move to the bench for this weekend's match against Fulham in favor of Roberto Firmino.
Liverpool are dealing with a plethora of injuries, but the attacking group is fairly fit, which should mean Mohamed Salah keeps his spot in the starting XI against Wolverhampton.
Diogo Jota was rested for Wednesday's Champions League match against Atalanta, but he could slot back into the lineup for Saturday's match against Brighton.
With a number of players returning from international duty, as well as others missing out due to positive COVID-19 tests, there could be plenty of lineup adjustments in Gameweek 9 of the Premier League.
Gabriel Jesus returned from injury this week, scoring off the bench against Olympiacos, and he has a chance to start Sunday's big match against Liverpool.
Mohamed Salah scored off the bench in Liverpool's Champions League match on Tuesday, and he's expected back in the starting XI this weekend against West Ham at Anfield
Ferran Torres scored off the bench in Manchester City's win over FC Porto in the Champions League on Wednesday, and it may be enough to get him a start Saturday against West Ham.
Sadio Mane is back in training, and he is expected to reclaim his starting spot up front with Roberto Firmino and Mohamed Salah for the Merseyside derby.
Trent Alexander-Arnold was one of the most prolific set-piece takers in the Premier League last season, and he's fully expected to maintain that role for Liverpool in the 2020/21 campaign.
RotoWire's Andrew Laird breaks down his team and player projections for Wednesday's match between Liverpool and Chelsea, which includes an expectation that Trent Alexander-Arnold will have another strong game.
Manchester United are heavily favored at home against West Ham on Wednesday, and fantasy players may want to consider Anthony Martial based on his projections.
Liverpool clinched the Premier League title earlier this week, and there could be some lineup rotation for their match Thursday against Manchester City, who are favored at the Etihad Stadium.
Harry Kane has struggled a bit under manager Jose Mourinho, but he has the highest probability to score according to Andrew Laird's projections for Thursday's match between Spurs and Sheffield United.
Chelsea are favored away to West Ham on Wednesday, and RotoWire's Andrew Laird is projecting a high-scoring game.